TModBase: deciphering the landscape of tRNA modifications and their dynamic changes from epitranscriptome data.

ABSTRACT: tRNA molecules contain dense, abundant modifications that affect tRNA structure, stability, mRNA decoding and tsRNA formation. tRNA modifications and related enzymes are responsive to environmental cues and are associated with a range of physiological and pathological processes. However, there is a lack of resources that can be used to mine and analyse these dynamically changing tRNA modifications. In this study, we established tModBase (https://www.tmodbase.com/) for deciphering the landscape of tRNA modification profiles from epitranscriptome data. We analysed 103 datasets generated with second- and third-generation sequencing technologies and illustrated the misincorporation and termination signals of tRNA modification sites in ten species. We thus systematically demonstrate the modific

SUBMITTER: Lei HT 

PROVIDER: S-EPMC9825477 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature