HUSCH: an integrated single-cell transcriptome atlas for human tissue gene expression visualization and analyses.

ABSTRACT: Understanding gene expression patterns across different human cell types is crucial for investigating mechanisms of cell type differentiation, disease occurrence and progression. The recent development of single-cell RNA-seq (scRNA-seq) technologies significantly boosted the characterization of cell type heterogeneities in different human tissues. However, the huge number of datasets in the public domain also posed challenges in data integration and reuse. We present Human Universal Single Cell Hub (HUSCH, http://husch.comp-genomics.org), an atlas-scale curated database that integrates single-cell transcriptomic profiles of nearly 3 million cells from 185 high-quality human scRNA-seq datasets from 45 different tissues. All the data in HUSCH were uniformly processed and annotated with a sta

SUBMITTER: Shi X 

PROVIDER: S-EPMC9825509 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature