RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modifications.

ABSTRACT: RNA modification is a dynamic and reversible process regulated by a series of writers, erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification homeostasis of their target genes, leading to the dysregulation of RNA metabolisms such as RNA stability and translation, and consequently to diseases such as cancer. A public repository hosting the regulatory relationships between WERs and their target genes will help in understanding the roles of RNA modifications in various physiological and pathological conditions. Previously, we developed a database named 'm6A2Target' to host targets of WERs in m6A, one of the most prevalent RNA modifications in eukaryotic cells. To host all RNA modification (RM)-related WER-target associations, we hereby present an updated databa

SUBMITTER: Bao X 

PROVIDER: S-EPMC9825529 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature