The protein common assembly database (ProtCAD)-a comprehensive structural resource of protein complexes.

ABSTRACT: Proteins often act through oligomeric interactions with other proteins. X-ray crystallography and cryo-electron microscopy provide detailed information on the structures of biological assemblies, defined as the most likely biologically relevant structures derived from experimental data. In crystal structures, the most relevant assembly may be ambiguously determined, since multiple assemblies observed in the crystal lattice may be plausible. It is estimated that 10-15% of PDB entries may have incorrect or ambiguous assembly annotations. Accurate assemblies are required for understanding functional data and training of deep learning methods for predicting assembly structures. As with any other kind of biological data, replication via multiple independent experiments provides important valida

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9825537 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature