TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms.

ABSTRACT: Characterization of the specific expression and chromatin profiles of genes enables understanding how they contribute to tissue/organ development and the mechanisms leading to diseases. Whilst the number of single-cell sequencing studies is increasing dramatically; however, data mining and reanalysis remains challenging. Herein, we systematically curated the up-to-date and most comprehensive datasets of sequencing data originating from 2760 bulk samples and over 5.1 million single-cells from multiple developmental periods from humans and multiple model organisms. With unified and systematic analysis, we profiled the gene expression and chromatin accessibility among 481 cell-types, 79 tissue-types and 92 timepoints, and pinpointed cells with the co-expression of target genes. We also enable

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC9825605 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature