CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase.

ABSTRACT: CIViC (Clinical Interpretation of Variants in Cancer; civicdb.org) is a crowd-sourced, public domain knowledgebase composed of literature-derived evidence characterizing the clinical utility of cancer variants. As clinical sequencing becomes more prevalent in cancer management, the need for cancer variant interpretation has grown beyond the capability of any single institution. CIViC contains peer-reviewed, published literature curated and expertly-moderated into structured data units (Evidence Items) that can be accessed globally and in real time, reducing barriers to clinical variant knowledge sharing. We have extended CIViC's functionality to support emergent variant interpretation guidelines, increase interoperability with other variant resources, and promote widespread dissemination o

SUBMITTER: Krysiak K 

PROVIDER: S-EPMC9825608 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature