NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways.

ABSTRACT:

Summary

Non-coding RNAs play important roles in transcriptional processes and participate in the regulation of various biological functions, in particular miRNAs and lncRNAs. Despite their importance for several biological functions, the existing signaling pathway databases do not include information on miRNA and lncRNA. Here, we redesigned a novel pathway database named NcPath by integrating and visualizing a total of 178 308 human experimentally validated miRNA-target interactions (MTIs), 32 282 experimentally verified lncRNA-target interactions (LTIs) and 4837 experimentally validated human ceRNA networks across 222 KEGG pathways (including 27 sub-categories). To expand the application potential of the redesigned NcPath database, we identified 556 798 reliable lncRNA-protein-cod

SUBMITTER: Li Z 

PROVIDER: S-EPMC9825761 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature