CanMethdb: a database for genome-wide DNA methylation annotation in cancers.

ABSTRACT:

Motivation

DNA methylation within gene body and promoters in cancer cells is well documented. An increasing number of studies showed that cytosine-phosphate-guanine (CpG) sites falling within other regulatory elements could also regulate target gene activation, mainly by affecting transcription factors (TFs) binding in human cancers. This led to the urgent need for comprehensively and effectively collecting distinct cis-regulatory elements and TF-binding sites (TFBS) to annotate DNA methylation regulation.

Results

We developed a database (CanMethdb, http://meth.liclab.net/CanMethdb/) that focused on the upstream and downstream annotations for CpG-genes in cancers. This included upstream cis-regulatory elements, especially those involving distal regions to genes, and TFBS ann

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9825769 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature