Dataset Information

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials.

ABSTRACT:

Background

Inclisiran, an siRNA administered twice-yearly, significantly reduced LDL cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into a lower risk of cardiovascular (CV) events is not yet established.

Methods and results

Patient-level, pooled analysis of ORION-9, -10 and -11, included patients with heterozygous familial hypercholesterolaemia, atherosclerotic CV disease (ASCVD), or ASCVD risk equivalent on maximally tolerated statin-therapy, randomized 1:1 to receive 284 mg inclisiran or placebo on Days 1, 90, and 6-monthly thereafter for 18 months. Prespecified exploratory endpoint of major cardiovascular events (MACEs) included non-adjudicated CV death, cardiac arrest, non-fatal myocardial infarction (MI), and fatal and non-fatal stroke, evaluated as part of safety assessments using a standard Medical Dictionary for Regulatory Activities basket. Although not prespecified, total fatal and non-fatal MI, and stroke were also evaluated. Mean LDL-C at baseline was 2.88 mmol/L. At Day 90, the placebo-corrected percentage reduction in LDL-C with inclisiran was 50.6%, corresponding to an absolute reduction of 1.37 mmol/L (both P < 0.0001). Among 3655 patients over 18 months, 303 (8.3%) experienced MACE, including 74 (2.0%) fatal and non-fatal MIs, and 28 (0.8%) fatal and non-fatal strokes. Inclisiran significantly reduced composite MACE [OR (95% CI): 0.74 (0.58-0.94)], but not fatal and non-fatal MIs [OR (95% CI): 0.80 (0.50-1.27)] or fatal and non-fatal stroke [OR (95% CI): 0.86 (0.41-1.81)].

Conclusion

This analysis offers early insights into the potential CV benefits of lowering LDL-C with inclisiran and suggests potential benefits for MACE reduction. These findings await confirmation in the larger CV outcomes trials of longer duration.

SUBMITTER: Ray KK

PROVIDER: S-EPMC9825807 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials.

Ray Kausik K KK Raal Frederick J FJ Kallend David G DG Jaros Mark J MJ Koenig Wolfgang W Leiter Lawrence A LA Landmesser Ulf U Schwartz Gregory G GG Lawrence David D Friedman Andrew A Garcia Conde Lorena L Wright R Scott RS

European heart journal 20230101 2

<h4>Background</h4>Inclisiran, an siRNA administered twice-yearly, significantly reduced LDL cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into a lower risk of cardiovascular (CV) events is not yet established.<h4>Methods and results</h4>Patient-level, pooled analysis of ORION-9, -10 and -11, included patients with heterozygous familial hypercholesterolaemia, atherosclerotic CV disease (ASCVD), or ASCVD risk equivalent on maximally tolerated statin-th ...[more]

PMID: 36331326

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Dataset Information

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials.

Background

Methods and results

Conclusion

Publications

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials.

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