Modelling the outcomes of different red blood cell transfusion strategies for the treatment of traumatic haemorrhage in the prehospital setting in the United Kingdom.

ABSTRACT:

Background and objectives

The limited supply and increasing demand of group O RhD-negative red blood cells (RBCs) have resulted in other transfusion strategies being explored by blood services that carry potential risks but may still provide an overall benefit to patients. Our aim was to analyse the potential economic benefits of prehospital transfusion (PHT) against no PHT.

Materials and methods

The impact of three PHT strategies (RhD-negative RBC, RhD-positive RBC and no transfusion) on quality-adjusted-life-years (QALYs) of all United Kingdom trauma patients in a given year and the subset of patients considered most at risk (RhD-negative females <50 years old), was modelled.

Results

For the entire cohort and the subset of patients, transfusing RhD-negative RBCs gen

SUBMITTER: Roberts B 

PROVIDER: S-EPMC9825834 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature