Continuum of sensory profiles in diabetes mellitus patients with and without neuropathy and pain.

ABSTRACT:

Background

Quantitative sensory testing (QST) assesses the functional integrity of small and large nerve fibre afferents and central somatosensory pathways; QST was assumed to provide insight into the mechanisms of neuropathy. We analysed QST profiles and phenotypes in patients with diabetes mellitus to study whether these could differentiate patients with and without pain and neuropathy.

Methods

A standardized QST protocol was performed and 'loss and gain of function' abnormalities were analysed in four groups of subjects: diabetic patients with painful (pDSPN; n = 220) and non-painful distal symmetric polyneuropathy (nDSPN; n = 219), diabetic patients without neuropathy (DM; n = 23) and healthy non-diabetic subjects (n = 37). Based on the QST findings, diabetic subjects we

SUBMITTER: Raputova J 

PROVIDER: S-EPMC9825847 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature