Choroid Plexus-Infiltrating T Cells as Drivers of Murine Neuropsychiatric Lupus.

ABSTRACT:

Objective

T cells are critical in the pathogenesis of systemic lupus erythematosus (SLE) in that they secrete inflammatory cytokines, help autoantibody production, and form autoreactive memory T cells. Although the contribution of T cells to several forms of organ-mediated damage in SLE has been previously demonstrated, the role of T cells in neuropsychiatric SLE (NPSLE), which involves diffuse central nervous system manifestations and is observed in 20-40% of SLE patients, is not known. Therefore, we conducted this study to evaluate how behavioral deficits are altered after depletion or transfer of T cells, to directly assess the role of T cells in NPSLE.

Methods

MRL/lpr mice, an NPSLE mouse model, were either systemically depleted of CD4+ T cells or intracerebroventricular

SUBMITTER: Moore E 

PROVIDER: S-EPMC9825865 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature