Control of Ca²⁺ signals by astrocyte nanoscale morphology at tripartite synapses.

ABSTRACT: Much of the Ca²⁺ activity in astrocytes is spatially restricted to microdomains and occurs in fine processes that form a complex anatomical meshwork, the so-called spongiform domain. A growing body of literature indicates that those astrocytic Ca²⁺ signals can influence the activity of neuronal synapses and thus tune the flow of information through neuronal circuits. Because of technical difficulties in accessing the small spatial scale involved, the role of astrocyte morphology on Ca²⁺ microdomain activity remains poorly understood. Here, we use computational tools and idealized 3D geometries of fine processes based on recent super-resolution microscopy data to investigate the mechanistic link between astrocytic nanoscale morphology and local Ca²⁺

SUBMITTER: Denizot A 

PROVIDER: S-EPMC9825906 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature