Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.

ABSTRACT: Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11-.76) throughout all significant subsegments. In this prospective community-based cohort of school-age children, these findings suggest that white matte

SUBMITTER: Roddy DW 

PROVIDER: S-EPMC9825926 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature