Strategies to detect and manage latent tuberculosis infection among household contacts of pulmonary TB patients in high TB burden countries - a systematic review and meta-analysis.

ABSTRACT:

Objective

To summarise latent tuberculosis infection (LTBI) management strategies among household contacts of bacteriologically confirmed pulmonary tuberculosis (TB) patients in high-TB burden countries.

Methods

PubMed/MEDLINE (NCBI) and Scopus were searched (January 2006 to December 2021) for studies reporting primary data on LTBI management. Study selection, data management and data synthesis were protocol-driven (PROSPERO-CRD42021208715). Primary outcomes were the proportions of LTBI, initiating and completing tuberculosis preventive treatment (TPT). Reported factors influencing the LTBI care cascade were qualitatively synthesised.

Results

From 3694 unique records retrieved, 58 studies from 23 countries were included. Most identified contacts were screened (median

SUBMITTER: Sagili KD 

PROVIDER: S-EPMC9825928 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature