Site Specific Preparation of N-Glycosylated Peptides: Thioamide-Directed Activation of Aspartate.

ABSTRACT: A site-specific method for the preparation of N-glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag^I -promoted, site-specific conversion to N-glycosylated Asn residues in peptides.

SUBMITTER: Taresh AB 

PROVIDER: S-EPMC9826000 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature