The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid-induced impaired wound healing.

ABSTRACT:

Background and purpose

Delayed wound healing is among the deleterious consequences of over-activation of the mineralocorticoid receptor (MR) induced by topical dermocorticoids. The role of dermal inflammation and angiogenesis in the benefits of MR blockade is unknown.

Experimental approach

Skin wounds were made on C57Bl6 mice after topical pretreatment with the dermocorticoid clobetasol. The impact of topical MR blockade by canrenoate on inflammation, angiogenesis, and the wound macrophage phenotype was analysed 5 days post-wounding. Similar experiments were conducted on mice with genetic deletion of the MR in myeloid cells.

Key results

Topical inhibition of the MR with canrenoate improved delayed wound healing through the resolution of prolonged inflammation in gluco

SUBMITTER: Nguyen VT 

PROVIDER: S-EPMC9826027 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature