Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods.

ABSTRACT:

Background

Ki67 reflects the proliferation activity in breast cancer (BC). However, an optimal method for its assessment in clinical settings has yet to be robustly defined. In this study we compared several methods to score Ki67 to identify a reliable and reproducible method for routine practice.

Methods

Sections from luminal BC cohort (n = 1662) were immunohistochemically stained with Ki67 and were assessed for the percentage, pattern, and intensity of expression. Ki67 positivity was evaluated using three methods: (i) quantification of Ki67-positive cells among 1000 invasive tumour cells within hotspot, (ii) average estimation of Ki67 within a defined hotspot, and (iii) average estimation of Ki67 positivity within the whole section. Time required for scoring, interobserver

SUBMITTER: Lashen A 

PROVIDER: S-EPMC9826086 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature