Hemolytic disease of the fetus and newborn caused by anti-s^D antibody in a GP.Mur/Mur Thai mother and review of the prevalence of s^D in Thai blood donors.

ABSTRACT:

Background

Low-prevalence antigen s^D (MNS23) is encoded by GYPB c.173C > G. Hemolytic disease of the fetus and newborn (HDFN) due to anti-s^D is rare. A mother delivered a newborn whose red blood cells (RBCs) were DAT-positive and was later diagnosed with HDFN. Serum from the mother was incompatible with the father's RBCs and was used to screen 184 Thai blood donors. This study aimed to investigate the cause of HDFN in a Thai family and determine the prevalence of s^D in Thai blood donors.

Materials and methods

Three family members and four blood donors were investigated in the study. Massively Parallel Sequencing (MPS) was used for genotyping. Standard hemagglutination techniques were used in titration studies, phenotyping, and enzyme/chemical

SUBMITTER: Lopez GH 

PROVIDER: S-EPMC9826107 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature