Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions.

ABSTRACT: Thyroid cancer is associated with genetic alterations, e.g. BRAF^V600E , which may cause carcinomatous changes in hormone-secreting epithelial cells. Epidemiological studies have shown that overnutrition is related to the development and progression of cancer. In this study, we attempted to identify the cell nonautonomous factor responsible for the progression of BRAF^V600E thyroid cancer under overnutrition conditions. We developed a mouse model for inducible thyrocyte-specific activation of BRAF^V600E , which showed features similar to those of human papillary thyroid cancer. LSL-Braf^V600E ;TgCreER^T2 showed thyroid tumour development in the entire thyroid, and the tumour showed more abnormal cellular features with mitochondrial abnormal

SUBMITTER: Kim JT 

PROVIDER: S-EPMC9826144 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature