Causal inference for planning randomised critical care trials: Protocol for a scoping review.

ABSTRACT:

Background

Randomised clinical trials in critical care are prone to inconclusiveness owing, in part, to undue optimism about effect sizes and suboptimal accounting for heterogeneous treatment effects. Planned predictive enrichment based on secondary critical care data (often very rich with respect to both data types and temporal granularity) and causal inference methods may help overcome these challenges, but no overview exists about their use to this end.

Methods

We will conduct a scoping review to assess the extent and nature of the use of causal inference from secondary data for planned predictive enrichment of randomised clinical trials in critical care. We will systematically search 10 general and specialty journals for reports published on or after 1 January 2018, of r

SUBMITTER: Kaas-Hansen BS 

PROVIDER: S-EPMC9826202 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature