Mouse dendritic cells in the steady state: Hypoxia, autophagy, and stem cell factor.

ABSTRACT: Dendritic cells (DCs) are innate immune cells with a central role in immunity and tolerance. Under steady-state, DCs are scattered in tissues as resting cells. Upon infection or injury, DCs get activated and acquire the full capacity to prime antigen-specific CD4⁺ and CD8⁺ T cells, thus bridging innate and adaptive immunity. By secreting different sets of cytokines and chemokines, DCs orchestrate diverse types of immune responses, from a classical proinflammatory to an alternative pro-repair one. DCs are highly heterogeneous, and physiological differences in tissue microenvironments greatly contribute to variations in DC phenotype. Oxygen tension is normally low in some lymphoid areas, including bone marrow (BM) hematopoietic niches; nevertheless, the possible impact

SUBMITTER: Barroeta Seijas AB 

PROVIDER: S-EPMC9826237 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature