Genetic and psychosocial influence on the association between early childhood infections and later psychiatric disorders.

ABSTRACT:

Objective

To evaluate the influence of extensive genetic and psychosocial confounding on the association between early childhood infection and five major psychiatric disorders METHODS: A case-cohort study including participants from the Danish iPSYCH2012 sample, a case-cohort sample where all cases born between May 1, 1981, and December 31, 2005, diagnosed with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar affective disorder (BIP), Major Depressive Disorder (MDD) or schizophrenia (SCZ), were identified and pooled with a representative sample (subcohort) of the Danish population. We used Cox proportional hazards regression customized to the case-cohort setup to calculate hazard ratios of outcome with 95% confidence intervals (CIs), followin

SUBMITTER: Debost JPG 

PROVIDER: S-EPMC9826256 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature