Protein kinase C-mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca²⁺ and elevates the temperature threshold.

ABSTRACT: The transient receptor potential melastatin type 2 (TRPM2) channel is a non-selective cation channel that has high Ca²⁺ permeability. TRPM2 is sensitive to warm temperatures and is expressed in cells and tissues that are maintained at core body temperature. TRPM2 activity is also regulated by endogenous factors including redox signalling, cytosolic Ca²⁺ and adenosine diphosphate ribose. As a result of its wide expression and function at core body temperature, these endogenous factors could regulate TRPM2 activity at body temperature under physiological and pathophysiological conditions. We previously reported that cellular redox signalling can lower TRPM2 temperature thresholds, although the mechanism that regulates these thresholds is unclear. Here, we used biochemic

SUBMITTER: Kashio M 

PROVIDER: S-EPMC9826287 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature