Diversity in new flagellum tip attachment in bloodstream form African trypanosomes.

ABSTRACT: The closely related parasites Trypanosoma brucei, T. congolense, and T. vivax cause neglected tropical diseases collectively known as African Trypanosomiasis. A characteristic feature of bloodstream form T. brucei is the flagellum that is laterally attached to the side of the cell body. During the cell cycle, the new flagellum is formed alongside the old flagellum, with the new flagellum tip embedded within a mobile transmembrane junction called the groove. The molecular composition of the groove is currently unknown, which limits the analysis of this junction and assessment of its conservation in related trypanosomatids. Here, we identified 13 proteins that localize to the flagellar groove through a small-scale tagging screen. Functional analysis of a subset of these proteins by RNAi and

SUBMITTER: Smithson L 

PROVIDER: S-EPMC9826329 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature