Anti- and Pro-Nociceptive mechanisms in neuropathic pain after human spinal cord injury.

ABSTRACT:

Background

Deficient endogenous pain modulation and increased nociceptive excitability are key features of central sensitization and can be assessed in humans by conditioned pain modulation (CPM, anti-nociceptive) and temporal summation of pain (TSP, pro-nociceptive), respectively. This study aimed to investigate these measures as proxies for central sensitization in subjects with chronic neuropathic pain (NP) after spinal cord injury (SCI).

Methods

In paraplegic subjects with NP (SCI-NP; n = 17) and healthy controls (HC; n = 17), parallel and sequential sham-controlled CPM paradigms were performed using pressure pain threshold at the hand, that is, above lesion level, as test stimulus. The conditioning stimulus was a noxious cold (verum) or lukewarm water bath (sham) applie

SUBMITTER: Lutolf R 

PROVIDER: S-EPMC9826499 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature