Direct incorporation of patient-specific efficacy and toxicity estimates in radiation therapy plan optimization.

ABSTRACT:

Purpose

Current radiation therapy (RT) treatment planning relies mainly on pre-defined dose-based objectives and constraints to develop plans that aim to control disease while limiting damage to normal tissues during treatment. These objectives and constraints are generally population-based, in that they are developed from the aggregate response of a broad patient population to radiation. However, correlations of new biologic markers and patient-specific factors to treatment efficacy and toxicity provide the opportunity to further stratify patient populations and develop a more individualized approach to RT planning. We introduce a novel intensity-modulated radiation therapy (IMRT) optimization strategy that directly incorporates patient-specific dose response models into the plann

SUBMITTER: Polan DF 

PROVIDER: S-EPMC9826508 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature