Dataset Information

The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions.

ABSTRACT: The COVID-19 pandemic has revealed the need for the increased integration of modelling and data analysis to public health, experimental, and clinical studies. Throughout the first two years of the pandemic, there has been a concerted effort to improve our understanding of the within-host immune response to the SARS-CoV-2 virus to provide better predictions of COVID-19 severity, treatment and vaccine development questions, and insights into viral evolution and the impacts of variants on immunopathology. Here we provide perspectives on what has been accomplished using quantitative methods, including predictive modelling, population genetics, machine learning, and dimensionality reduction techniques, in the first 26 months of the COVID-19 pandemic approaches, and where we go from here to improve our responses to this and future pandemics.

SUBMITTER: Gazeau S

PROVIDER: S-EPMC9826539 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions.

Gazeau Sonia S Deng Xiaoyan X Ooi Hsu Kiang HK Mostefai Fatima F Hussin Julie J Heffernan Jane J Jenner Adrianne L AL Craig Morgan M

Immunoinformatics (Amsterdam, Netherlands) 20230108

The COVID-19 pandemic has revealed the need for the increased integration of modelling and data analysis to public health, experimental, and clinical studies. Throughout the first two years of the pandemic, there has been a concerted effort to improve our understanding of the within-host immune response to the SARS-CoV-2 virus to provide better predictions of COVID-19 severity, treatment and vaccine development questions, and insights into viral evolution and the impacts of variants on immunopat ...[more]

PMID: 36643886

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Dataset Information

The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions.

Publications

The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions.

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