GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.

ABSTRACT: The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke. Here we demonstrate that GPR37 functions as a critical negative regulator of progenitor cell dynamics and gliosis following ischemic injury. In the central nervous system, GPR37 is enriched in mature oligodendrocytes, but following injury we have found that its expression is dramatically increased within a population of Sox2-positive progenitor cells. Moreover, the genetic deletion of GPR37 did not alter the number of mature oligodendrocytes following inju

SUBMITTER: Owino S 

PROVIDER: S-EPMC9826632 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature