Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET).

ABSTRACT:

Purpose

Exploring synaptic density changes during brain growth is crucial to understanding brain development. Previous studies in nonhuman primates report a rapid increase in synapse number between the late gestational period and the early neonatal period, such that synaptic density approaches adult levels by birth. Prenatal synaptic development may have an enduring impact on postnatal brain development, but precisely how synaptic density changes in utero are unknown because current methods to quantify synaptic density are invasive and require post-mortem brain tissue.

Methods

We used synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) radioligands [¹¹C]UCB-J and [¹⁸F]Syn-VesT-1 to conduct the first assessment of synaptic density

SUBMITTER: Rossano S 

PROVIDER: S-EPMC9826644 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature