Micropatterned photothermal double-layer periosteum with angiogenesis-neurogenesis coupling effect for bone regeneration.

ABSTRACT: The abundant neurovascular network in the periosteal fibrous layer is essential for regulating bone homeostasis and repairing bone defects. However, the majority of the current studies only focus on the structure or function, and most of them merely involve osteogenesis and angiogenesis, lacking an in-depth study of periosteal neurogenesis. In this study, a photothermal double-layer biomimetic periosteum with neurovascular coupling was proposed. The outer layer of biomimetic periosteum is a conventional electrospinning membrane to prevent soft tissue invasion, and the inner layer is an oriented nanofiber membrane to promote cell recruitment and angiogenesis. From the perspective of functional bionics, based on the whitlockite (WH) similar to bone composition, we doped Nd (the trivalent for

SUBMITTER: Li Q 

PROVIDER: S-EPMC9826821 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature