Inhibition of MicroRNA-92a Improved Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats via Suppressing Oxidative Stress and Endothelial Dysfunction.

ABSTRACT:

Purpose

To determine whether microRNA could be a therapy target of erectile dysfunction (ED) and the underlying mechanisms.

Materials and methods

Eight-week-old fasting male SD rats were intraperitoneally injected with streptozotocin to construct diabetic rat models. Diabetic ED rats were treated with miRNA-92a inhibitor. The cavernous nerves were electrically stimulated to measure the intracavernous pressure and mean arterial pressure of rats in each group. After the detection, the penile cavernous tissues are properly stored for subsequent experiments. Rat aortic endothelial cells were used in in vitro studies.

Results

The expression of miR-92a was significantly increased in the corpus cavernosum of Streptozocin (STZ)-induced diabetic rats and injection of mi

SUBMITTER: Tang Z 

PROVIDER: S-EPMC9826907 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature