Linear Energy Transfer and Relative Biological Effectiveness Investigation of Various Structures for a Cohort of Proton Patients With Brain Tumors.

ABSTRACT:

Purpose

The current knowledge on biological effects associated with proton therapy is limited. Therefore, we investigated the distributions of dose, dose-averaged linear energy transfer (LET_d), and the product between dose and LET_d (DLET_d) for a patient cohort treated with proton therapy. Different treatment planning system features and visualization tools were explored.

Methods and materials

For a cohort of 24 patients with brain tumors, the LET_d, DLET_d, and dose was calculated for a fixed relative biological effectiveness value and 2 variable models: plan-based and phenomenological. Dose threshold levels of 0, 5, and 20 Gy were imposed for LET_d visualization. The relationship between physical dose and LET

SUBMITTER: Vaniqui A 

PROVIDER: S-EPMC9827037 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature