Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a ¹H-MRS study.

ABSTRACT: Proton magnetic resonance spectroscopy (¹H-MRS) holds promise for revealing and understanding neurodegenerative processes associated with cognitive and functional impairments in aging. In the present study, we examined the neurometabolic correlates of balance performance in 42 cognitively intact older adults (healthy controls - HC) and 26 older individuals that were diagnosed with mild cognitive impairment (MCI). Neurometabolite ratios of total N-acetyl aspartate (tNAA), glutamate-glutamine complex (Glx), total choline (tCho) and myo-inositol (mIns) relative to total creatine (tCr) were assessed using single voxel ¹H-MRS in four different brain regions. Regions of interest were the left hippocampus (HPC), dorsal posterior cingulate cortex (dPCC), left sensorimotor cor

SUBMITTER: Levin O 

PROVIDER: S-EPMC9827054 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature