Cold Ischemia Time, Kidney Donor Profile Index, and Kidney Transplant Outcomes: A Cohort Study.

ABSTRACT:

Rationale & objective

An average of 3,280 recovered deceased donor kidneys are discarded annually in the United States. Increased cold ischemia time is associated with an increased rate of organ decline and subsequent discard. Here we examined the effect of prolonged cold ischemia time on kidney transplant outcomes.

Study design

Retrospective observational study.

Setting & participants

Recipients of deceased donor kidney transplants in the United States from 2000 to 2018.

Exposure

Recipients of deceased donor kidneys were divided based on documented cold ischemia time: ≤16, 16-24, 24-32, 32-40, and >40 hours.

Outcomes

The incidence of delayed graft function, primary nonfunction, and 10-year death-censored graft survival.

Analytical approach

The Ka

SUBMITTER: Lum EL 

PROVIDER: S-EPMC9827060 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature