Comparison of medication adherence to different oral anticoagulants: population-based cohort study.

ABSTRACT:

Objective

Previous observational studies have yielded conflicting results on whether medication adherence differs between patients receiving warfarin and direct oral anticoagulants (DOACs). Importantly, no study has adequately accounted for warfarin dosing being continuously modified based on INR values while dosing of DOACs is fixed. We aimed to compare non-adherence between new users of apixaban, dabigatran, rivaroxaban and warfarin in a population-based cohort.

Methods

New users of apixaban, dabigatran, rivaroxaban and warfarin from 2014 to 2019 living in the Icelandic capital area were included. Non-adherence was defined as proportion of days covered below 80%. Inverse probability weighting was used to yield balanced study groups and non-adherence was compared using logi

SUBMITTER: Ingason AB 

PROVIDER: S-EPMC9827257 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature