Characterization of ligamentum flavum hypertrophy based on m6A RNA methylation modification and the immune microenvironment.

ABSTRACT:

Objective

N6-methyladenosine (m6A) has been implicated in the progression of several diseases, and the role of epigenetic regulation in immunity is emerging, particularly for RNA m6A modification. However, it is unclear how m6A-related genes affect the immune microenvironment of ligamentum flavum hyperplasia (LFH). Therefore, we aimed to investigate the effect of m6A modification on the LFH immune microenvironment.

Methods

The GSE113212 dataset was downloaded from the Gene Expression Omnibus (GEO) database. We systematically analyzed m6A regulators in eight patient samples and the corresponding clinical information of the samples. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA) and protein-protein interactions (PPIs) we

SUBMITTER: He Z 

PROVIDER: S-EPMC9827295 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature