Dysfunctional network of hub genes in hypertrophic cardiomyopathy patients.

ABSTRACT:

Background

Considering it is one of the major causes of sudden cardiac arrest, the proper management of hypertrophic cardiomyopathy (HCM) is essential. However, efficient treatment options for this disease are still lacking. The discovery of HCM-associated hub genes may help in diagnosis and offer a reliable tool for developing effective therapeutic strategies.

Methods

We examined HCM-based gene expression datasets (GSE36961) from the Gene Expression Omnibus (GEO) database for the identification of differentially expressed genes (DEGs), PPI network development, module screening, and shortlisting of hub genes via GEOR2, STRING, and Cytoscape. Moreover, we also used another HCM-based gene expression dataset (GSE32453) for the expression validation of hub genes. Following this,

SUBMITTER: Wu S 

PROVIDER: S-EPMC9827312 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature