SARS-CoV-2-correlated ASGR1 is a novel potential marker for the treatment and identification of multiple human cancers.

ABSTRACT:

Objectives

Cancer patients are reported to be more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the COVID-19 (the Corona Virus Disease 2019) patients with cancer suffer from certain serious complications. ASGR1 has been recently identified as a novel receptor of SARS-CoV-2 in human cells; however, there are limited studies on ASGR1 in various human cancers.

Methods

This study utilized a comprehensive analysis of COVID-19-related ASGR1 in multiple human cancers based on 18,589 multi-center samples. Using Wilcoxon rank-sum analysis, a difference in ASGR1 expression between cancer and control tissues was detected. Cox regression analysis, Kaplan-Meier curves, and receiver operating characteristic curves were utiliz

SUBMITTER: Huang T 

PROVIDER: S-EPMC9827325 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature