Prognostic value and risk model construction of hypoxic stress-related features in predicting gastric cancer.

ABSTRACT:

Objective

Hypoxia promotes tumor progression from multiple aspects, including metabolism, proliferation, migration and angiogenesis. Therefore, a thorough understanding of the impact of hypoxia on gastric adenocarcinoma (STAD) is warranted. The aim of the present study was to find a prognostic model of hypoxia in gastric cancer (GC) and its relationship with the immune microenvironment.

Methods

Distinct hypoxia-related patterns were identified with an unsupervised consensus clustering algorithm in STAD patients from the Gene Expression Omnibus (GEO) and the cancer genome atlas (TCGA) cohorts. The different biological processes among different hypoxia-related clusters were then explored with the algorithm of single sample gene set enrichment analysis. Then hypoxia-related Hub

SUBMITTER: Guo J 

PROVIDER: S-EPMC9827339 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature