Aberrant corticospinal tract characteristics in prodromal PD: A diffusion tensor imaging study.

ABSTRACT:

Introduction

Parkinson's disease (PD) is typically diagnosed when motor symptoms first occur. However, PD-related non-motor symptoms may appear several years before diagnosis. REM sleep behaviour disorder (RBD) and olfactory deficits (hyposmia) are risk factors, but they are not specific for predicting progression towards PD. Other PD-related markers, for example brain imaging markers, may help to identify preclinical PD in hyposmic RBD patients. Studies have reported abnormal structural characteristics in the corticospinal tract (CST) of PD patients, but it is unclear whether hyposmic RBD patients have similar abnormalities that may help to predict PD in these individuals. This study examined whether CST abnormalities may be a potential marker of PD risk by using diffusion tensor

SUBMITTER: Pimer LJ 

PROVIDER: S-EPMC9827373 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature