Cerebellar gray matter alterations predict deep brain stimulation outcomes in Meige syndrome.

ABSTRACT:

Background

The physiopathologic mechanism of Meige syndrome (MS) has not been clarified, and neuroimaging studies centering on cerebellar changes in MS are scarce. Moreover, even though deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been recognized as an effective surgical treatment for MS, there has been no reliable biomarker to predict its efficacy.

Objective

To characterize the volumetric alterations of gray matter (GM) in the cerebellum in MS and to identify GM measurements related to a good STN-DBS outcome.

Methods

We used voxel-based morphometry and lobule-based morphometry to compare the regional and lobular GM differences in the cerebellum between 47 MS patients and 52 normal human controls (HCs), as well as between 31 DBS responders and 10

SUBMITTER: Liu B 

PROVIDER: S-EPMC9827385 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature