Prostatic artery occlusion: initial findings on pathophysiological response in a canine prostate model.

ABSTRACT:

Background

Prostatic artery embolization (PAE) is an alternative treatment for symptomatic benign prostatic hyperplasia (BPH) in men. A technical modification of conventional PAE has been developed in a canine prostate model consisting of prostatic artery occlusion (PAO) using Onyx^® whose therapeutic effect is prostate shrinkage. However, the underlying mechanisms are not well clarified. The purpose was to evaluate the biological mechanisms responsible for therapeutic effects of PAO in the canine prostate.

Methods

Ten adult male beagles (5.0±0.82 years) underwent PAO with Onyx-18 (n=7) and prostatic artery angiography as control (n=3). Blood samples were taken at different time points of follow-up (baseline, 1 week, 2 weeks, 1 month, 3 months and 6 months) to meas

SUBMITTER: Lucas-Cava V 

PROVIDER: S-EPMC9827397 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature