The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.

ABSTRACT: Host defense against infections encompasses both resistance, which targets microorganisms for neutralization or elimination, and resilience/disease tolerance, which allows the host to withstand/tolerate pathogens and repair damages. In Drosophila, the Toll signaling pathway is thought to mediate resistance against fungal infections by regulating the secretion of antimicrobial peptides, potentially including Bomanins. We find that Aspergillus fumigatus kills Drosophila Toll pathway mutants without invasion because its dissemination is blocked by melanization, suggesting a role for Toll in host defense distinct from resistance. We report that mutants affecting the Toll pathway or the 55C Bomanin locus are susceptible to the injection of two Aspergillus mycotoxins, restrictocin and verruculog

SUBMITTER: Xu R 

PROVIDER: S-EPMC9827548 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature