Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway.

ABSTRACT: Chronic inflammation represents a major threat to human health since long-term systemic inflammation is known to affect distinct tissues and organs. Recently, solid evidence demonstrated that chronic inflammation affects hematopoiesis; however, how chronic inflammation affects hematopoietic stem cells (HSCs) on the mechanistic level is poorly understood. Here, we employ a mouse model of chronic multifocal osteomyelitis (CMO) to assess the effects of a spontaneously developed inflammatory condition on HSCs. We demonstrate that hematopoietic and nonhematopoietic compartments in CMO BM contribute to HSC expansion and impair their function. Remarkably, our results suggest that the typical features of murine multifocal osteomyelitis and the HSC phenotype are mechanistically decoupled. We show t

SUBMITTER: Grusanovic S 

PROVIDER: S-EPMC9827550 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature