Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice.

ABSTRACT:

Background

Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity. Since pelvic organs share common sensory pathways, it is likely that those syndromes involve a cross-sensitization of the bladder and the colon. The precise pathophysiology remains poorly understood.

Aim

To develop a model of chronic bladder-colon cross-sensitization and to investigate the mech-anisms involved.

Methods

Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia. Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions. Myeloperoxidase, used as

SUBMITTER: Atmani K 

PROVIDER: S-EPMC9827584 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature