Genetic and Environmental Influences on Structural and Diffusion-Based Alzheimer's Disease Neuroimaging Signatures Across Midlife and Early Old Age.

ABSTRACT:

Background

Composite scores of magnetic resonance imaging-derived metrics in brain regions associated with Alzheimer's disease (AD), commonly termed AD signatures, have been developed to distinguish early AD-related atrophy from normal age-associated changes. Diffusion-based gray matter signatures may be more sensitive to early AD-related changes compared with thickness/volume-based signatures, demonstrating their potential clinical utility. The timing of early (i.e., midlife) changes in AD signatures from different modalities and whether diffusion- and thickness/volume-based signatures each capture unique AD-related phenotypic or genetic information remains unknown.

Methods

Our validated thickness/volume signature, our novel mean diffusivity (MD) signature, and a magnetic r

SUBMITTER: Williams ME 

PROVIDER: S-EPMC9827615 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature