Association between radiotherapy and risk of second primary malignancies in patients with resectable lung cancer: a population-based study.

ABSTRACT:

Background

The most common form of treatment for non-metastatic lung cancer is surgery-based combination therapy, which may also include adjuvant radiotherapy or chemotherapy. Second primary malignancies (SPMs) are uncommon but significant radiation side effects in patients with resectable lung cancer, and SPMs have not been adequately investigated. Our study aims to assess the correlations of radiotherapy with the development of SPMs in patients with resectable lung cancer.

Methods

We screened for any primary malignancy that occurred more than five years after the diagnosis of resectable lung cancer. Based on the large cohort of the Surveillance, Epidemiology and End Results database, radiotherapy-correlated risks were estimated using the Poisson regression analysis and the

SUBMITTER: Zhou B 

PROVIDER: S-EPMC9827664 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature