Leading mediators of sex differences in the incidence of dementia in community-dwelling adults in the UK Biobank: a retrospective cohort study.

ABSTRACT:

Background

Little is known regarding whether sex assigned at birth modifies the association between several predictive factors for dementia and the risk of dementia itself.

Methods

Our retrospective cohort study included 214,670 men and 214,670 women matched by age at baseline from the UK Biobank. Baseline data were collected between 2006 and 2010, and incident dementia was ascertained using hospital inpatient or death records until January 2021. Mediation analysis was tested for 133 individual factors.

Results

Over 5,117,381 person-years of follow-up, 5928 cases of incident all-cause dementia (452 cases of young-onset dementia, 5476 cases of late-onset dementia) were documented. Hazard ratios (95% CI) for all-cause, young-onset, and late-onset dementias associated wi

SUBMITTER: Shang X 

PROVIDER: S-EPMC9827665 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature