Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach.

ABSTRACT:

Background

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by altered cellular metabolism in the brain. Several of these alterations have been found to be exacerbated in females, known to be disproportionately affected by AD. We aimed to unravel metabolic alterations in AD at the metabolic pathway level and evaluate whether they are sex-specific through integrative metabolomic, lipidomic, and proteomic analysis of mouse brain tissue.

Methods

We analyzed male and female triple-transgenic mouse whole brain tissue by untargeted mass spectrometry-based methods to obtain a molecular signature consisting of polar metabolite, complex lipid, and protein data. These data were analyzed using multi-omics factor analysis. Pathway-level alterati

SUBMITTER: Strefeler A 

PROVIDER: S-EPMC9827669 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature